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Autor[ Mayer JG, Goehl K J[ 22.5 Z. Phytother. 22, Nr. 5, 264--270 2001 ; Das Standardwerk der Klostermedizin: der , Macer floridus' * The standard work of monastery medicine: the , Macer floridus' ; Zusammenfassung Das Gedicht , De viribus herbarum' bzw. , Macer floridus', das meistgelesene Kruterbuch des Mittelalters, geht nicht auf den antiken Dichter Aemilius Macer aus Verona, sondern wahrscheinlich auf einen Mnch namens Odo Magdunensis aus dem 11. Jahrhundert zurck. Voruntersuchungen deuten auf eine phnomenale Wirkung hin: Als Quelle des , Gart der Gesundheit' Mainz 1485 ; erreichen Anweisungen aus dem , Macer' die Goethezeit; Spuren lassen sich sogar in , Hagers Handbuch der Pharmazeutischen Praxis' unter den volkstmlichen Anwendungen finden. Summary The poem entitled , De viribus herbarum' or rather , Macer floridus', the most read herbal book of the Middle Ages, is not attributable to the antiquity poet Aemilius Macer from Verona but probably to a monk called Odo Magdunensis during the 11th Century. Preliminary examinations point towards a phenomenal effect: Via , Gart der Gesundheit' Mainz, 1485 ; , sources of medical instruction from , Macer' are found during Goethe's period. Traces are even found in the latest edition of Hager's Handbook of Pharmaceutical Practice with regard to traditional drug application. Keywords Monastery medicine, Macer floridus, Gart der Gesundheit, historically critical phytotherapy Autor[ Mayer-Nicolai Ch, Mayer JG J[ 22.6 Z. Phytother. 22, Nr. 6, 294-300 2001 ; Der Wissenschaftler Leonhart Fuchs: Philologe, Mediziner und Botaniker Leonhart Fuchs the scientist: philologist, medic and botanist ; Zusammenfassung Auch wenn Leonhart Fuchs zurecht als einer der Vter der Botanik gilt, der Pflanzenexkursionen unternahm und einen eigenen botanischen Garten unterhielt, darf nicht vergessen werden, dass seine Arbeitsweise stark philologisch ausgerichtet und seine Denkweise radikal humanistisch und protestantisch geprgt war. Die ausschlieliche Akzeptanz der groen antiken Autoren, wie Dioskurides, Plinius und ganz besonders Galen sowie seine guten botanischen Kenntnisse bewahrten ihn vor manchem Irrtum seiner Vorgnger und seiner Zeitgenossen. Auf Grund seiner geradezu fanatischen Ablehnung der arabisch geprgten medizinischen und pharmazeutischen Fachliteratur des Mittelalters bersah er jedoch auch manches Gute und manchen Fortschritt. Obwohl er zu Lebzeiten ein hoch geachteter Mediziner und Autor mehrerer sehr erfolgreicher Lehrbcher war, wurde er auf diesem Gebiet schnell berholt, whrend , De Historia stirpium' und sein , New Kreterbuch' nicht zuletzt wegen der berragenden Qualitt der Pflanzenabbildungen ihm eine berzeitliche Geltung verschafften. Summary Even though Leonhart Fuchs is rightly regarded as one of the founding fathers of botany, who took part in plant excursions and maintained his own botanic garden, it should be remembered that his working methods had a strong philological influence while his way of thinking was radically humanistic and protestant. The exclusive acceptance of the big authors of antiquity, for example, Dioskurides, Plinius and particularly important Galen as well as his good botanic knowledge, protected him from some of the mistakes made by his predecessors and contemporaries. However, due to his almost fanatical rejection of arabically influenced medicine and specialized pharmaceutical literature of the Middle Ages, he overlooked some positive sides and progress of the aforesaid. Although he was a highly respected medic and the author of very successful textbooks during his lifetime, he was quickly overtaken in this sphere. None.
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Other References ASHP Commission on Therapeutics. ASHP therapeutic position statement on the use of statins in the prevention of atherosclerotic vascular disease in adults. J Health Syst Pharm. 2003; 60: 593-98. Irons BK, Snella KA, McCall K, et al. Update on the management of dyslipidemia. J Health Syst Pharm. 2002; 59: 1615-25. Abramowicz M, ed. Three new drugs for hyperlipidemia. The Medical Letter. 2003 March3 45: 17-19. Abramowicz M, ed. Choice of lipid-regulating drugs. The Medical Letter. 2001 May 28 43: 43-48. Wickersham R. Antihyperlipidemic agents. Drugs Facts and Comparisons. St. Louis, MO. 2003. Pasternak RC, Smith SC, Bairey CN, et al. ACC AHA NHLBI clinical advisory on the use and safety of statins. Circulation. 2002; 106: 1024-28, for example, xenical obesity drug.
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Benefit instead from share gains? Are plan or benefit managers rejecting prescription transactions for products contractually entitled to the same treatment as other in-class products on the same tier of the formulary? Or is product underperformance unrelated to plan treatment and a result instead of shortcomings in the manufacturer's regional or account sales force, as MCOs and benefit managers sometimes claim? Most manufacturers have difficulty ascertaining the answers to these questions--if indeed they are asked at all. As a result, when products perform below expectations in certain accounts or regions, the concern often flies under the radar. It's worth putting the problem on the radar, however. Companies need to invest in monitoring and data gathering, as well as analytical and modeling capabilities. They need more experience at isolating the factors that cause variations in product performance across different formularies. And they need the information as well as the relexes to intervene when it's evident that a product is falling below it's fair share. The pharmaceutical industry is only beginning to create the right tools and techniques to work in a more competitive world where MCOs are gaining influence. Just as consumer goods manufacturers have grappled with growing channel power in the last two decades, drug firms now need better ways to assign MCO investment, pick the right battles with the sector and preserve the value of their products. Fair share evaluation and related interventions offer an effective and practical means for making the most of the investments with MCOs. And they provide the forum for more productive dialogues between account teams, brand managers, sales and finance executives to calibrate MCO spending. Drug firms must regain some of the market power and negotiating leverage they are increasingly losing to MCOs. Securing a brand's fair share doesn't lessen the importance of cost management, product development, pricing, patent protection and related actions by pharma companies. But the tools to track and negotiate fair share do provide a new set of resources to improve performance and returns. Anil Shrivastava and David Bellaire are partners with Bain & Co. in New York. Ashish Singh is a Bain partner in Boston. Comments? Send an e-mail message to the editor at rlongman windhover, for example, ativan.
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Enzyme has in physiological processes to be explored. Although the enzyme is known to be widely distributed, the lack of potent inhibitors has previously made it difficult to determine its role in the body. More importantly, evidence to support a major role for the enzyme in regulating the growth of some breast cancers has been accumulating for many years. With the advent of potent inhibitors, it will now be possible to explore their therapeutic potential. Indeed, one of the inhibitors detailed in this review, 667COUMATE, an irreversible sulfatase inhibitor, has now entered a phase I trial in postmenopausal women with breast cancer. Preliminary results obtained from a small number of patients are encouraging and have revealed that more than 90% inhibition of STS in PBLs can be achieved with low doses of the drug 317 ; . Additional phase II III trials will be required to confirm whether such STS inhibitors are to have a place in the armory against breast cancer. There is also growing interest in the pursuit of reversible sulfatase inhibitors, and this is an area that will undoubtedly develop over the next few years as novel templates are synthesized. If the sulfatase inhibitor concept is successful, future trials of STS inhibitors in combination with aromatase inhibitors, or possibly DASItype compounds, will be required to determine whether such combinations offer any advantages over the use of singleagent therapy. Also, there are many other potential disease targets beyond oncology that could receive attention after an initial clinical success. An important property of this class of aryl sulfamates is their ability to be transported in rbcs and to avoid first-pass inactivation during transit through the liver. This property results from their ability to interact with and inhibit a number of CAs that may contribute to the overall efficacy of this class of drug. With the publication of several crystal structures for sulfamates interacting with CA, the molecular features that and abilify and xenical, because buy phentermine online.
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Hi-Tech Park in Shanghai; 108 and AstraZeneca is planning to do likewise.109 Meanwhile, Novartis is building an $83m R&D centre in Suzhou, near Shanghai; and GlaxoSmithKline is contemplating a move to China, too.110 Similarly, Eli Lilly, Novartis and GlaxoSmithKline have all set up research centres in Singapore.111 Novartis has also just embarked on a new clinical research venture in Indonesia.112 AstraZeneca has opened a process R&D laboratory in Bangalore.113 And GlaxoSmithKline plans to set up a global drug development support centre in Mumbai with Indian software firm Tata Consultancy Services.114 But these investments are tiny, compared with the amount Big Pharma is spending on R&D in the West. Moreover, although the majority of multinationals are keen to expand their presence in Asia, relatively few are focusing on research. In a survey recently conducted by PricewaterhouseCoopers, only 8% of respondents said they were interested in doing more research in Asia, whereas 50% wanted to increase their sales and marketing activities, and 25% to increase their manufacturing activities, in the region.115 This may prove a rather short-sighted approach. If Pharma is to get access to the basic research it needs, it will either have to establish a much stronger footprint in Asia or forge close links with the most reputable centres of scientific excellence in the area. That, in turn, means it will have to overcome barriers of language and culture. And, as experience in the IT sector shows, following the herd can prove a costly mistake. Many parts of India are now short of the very.
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