Pheniramine

The self-reported mental and general health status of patients was worse than in the control subjects.
The narcotic antagonists, naloxone, nalorphine and levallorphan, are specific antidotes against the respiratory depression produced by propoxyphene. An appropriate dose of one of these antagonists should be administered preferably by the intravenous route, simultaneously with efforts at respiratory resuscitation. The antagonist should be repeated as necessary until the patient's condition remains satisfactory. In addition to the use of a narcotic antagonist, the patient may require careful titration with an anticonvulsant to control convulsions. Analeptic drugs for example, caffeine or amphetamine ; should not be used because of their tendency to precipitate convulsions. Oxygen, intravenous fluids vasopressors and other supportive measures should be employed as indicted. Gastric lavage may be helpful. Activated charcoal can absorb a significant amount of ingested propoxyphene. Dialysis is of little value in poisoning by propoxyphene alone. Overdosage of antihistamines may be fatal especially in children. Overdosage with Chlorpheniramine Maleate associated with antimuscarinic, extrapyrimidal, gastro-intestinal and Central Nervous System effects. In children Central Nervous System stimulation predominates. In adults Central Nervous System depression is more common with drowsiness, coma and convulsions, progressing to respiratory failure or possible cardiovascular collapse. In severe overdosage with antihistamines or caffeine the stomach should be emptied. Activated charcoal has been given, as have saline laxatives. Convulsions may be controlled with diazepam although it has been suggested that Central Nervous System depressant should be avoided with overdose of antihistamines. Cerebral stimulants may increase the risk of convulsions and should be avoided. Severe overdosage of Caffeine or idiosyncrasy may lead to maniac behaviour, diuresis and repeated vomiting with extreme thirst, tremor, delirium, hyperthermia, tachycardia, tachypnoea, electrolyte disturbances, convulsions and death. See also " Side-effects and special precautions " Other treatment is symptomatic and supportive. IDENTIFICATION White, round, flat tablet bisected on one side. PRESENTATION Securitainers packed with 20, 100 or 200 tablets. Cello Strip Packs containing 20 tablets. STORAGE INSTRUCTIONS Store in well-closed containers below 30 oC. Protect from light. KEEP OUT OF REACH OF CHILDREN. REGISTRATION NUMBER J 2.8 252 NAME AND BUSINESS ADDRESS OF APPLICANT Adcock Ingram Limited Adcock Ingram Park 17 Harrison Avenue Bryanston. Private Bag X69 Bryanston, 2021 DATE OF PUBLICATION OF THIS PACKAGE INSERT 30 November 1978.

Ately affects the population older than 60 years, the group likely to be contending with numerous other medical concerns. Unfortunately, the discomfort of shingles represents only the beginning of the problem for many patients who suffer for months or years from debilitating PHN.38 A large prospective, randomized, placebo-controlled, double-blind study was recently completed by the Shingles Prevention Study Group.38 The study included 38, 546 adults aged 60 years or older and used a highly potent zoster vaccine several times the concentration of that used for primary vaccination against chickenpox in children ; . Vaccine recipients showed reduced burden of illness incidence and severity ; by greater than half 61.1%; P .001 ; . The incidence of herpes zoster was reduced by 51.3%, and, most significantly, incidence of PHN was reduced by 66.5% P .001 ; . The authors suggest that the decreased morbidity due to PHN more than adequately offsets the cost of large-scale immunization of individuals aged 60 years or older. 38 The vaccine awaits FDA approval, and it remains to be seen whether the FDA will require further confirmatory trials for this promising vaccine.
Examples include the following: cough suppressants, such as dextromethorphan hydrobromide and codeine; antihistamines such as chlorpheniramine maleate, brompheniramine maleate, loratidine, astemizole, diclofenac sodium and terfenadine; decongestants such as pseudoephedrine and phenylephrine; antihypertensives such as nifedipine, verapamil, enalapril and salts thereof, metoprolol, metoprolol succinate, metoprolol fumarate, metoprolol tartarate; calcium channel blockers such as verapamil, diltiazam, nifedipine, nimodipine, felodipine, nicardipine, isradipine and amlodipine; antidiabetic agents such as glipizide and ibromectin; proton pump inhibitors such as omeprazole; h2 receptor antagonists such as cimetidine, ranitidine, famotidine, nizatidine; carbamazepine; anti-parkinson agents such as selegiline, carbidopa levodopa, pergolide, bromocriptine, amantadine, trihexyphenidyl hcl; antiviral agents including antiherpesvirus agents such as acyclovir, famciclovir, foscarnet, ganciclovir; antiretroviral agents such as didanosine, stavudine, zalcitabine, zidovudine; and others such as amantadine, interferon alpha, ribavirin, rimantadine; and other therapeutic agents such as cimetidine, propiomazine, phenytoin, tacrine, propiazam, proplazam.

History of Pheniramine

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