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The 2000-2001 therapeutic mix trend was 3.7 percent. As has been the case in past years, there is significant variability in therapeutic mix across therapy classes in 2001. Five classes had therapeutic mix changes of greater than 6.0 percent while one class had a therapeutic mix trend of less than -6.0 percent. Antiasthmatics topped all classes with a combined mix change of 10.6 percent. The largest part of this increase was due to the increasing popularity of combination products, often available with new delivery systems. The drug that contributed the most to mix trend was Advair Diskus, which grew to a market share of 4.3 percent in 2001. At $131.56 per prescription, this drug was about $70 more costly than the average drug cost within the class, but that cost is offset somewhat by the fact that Advair contains two branded prescription drugs Serevent and Flovent ; in one inhaler. Anticonvulsants experienced the second-highest therapeutic mix change due to the three percentage point increase in the market share of Neurontin and the decrease in Depakote's market share by slightly more than three points. The decline in the use of Depakote is likely due to cannibalization by Depakote ER, introduced in 2000. Indicated only for migraine prophylaxis, Depakote ER is classified not as an anticonvulsant but rather as a migraine product. Regular Depakote has indications for both migraine prophylaxis and epilepsy. The class with the third highest therapeutic mix increase was antidiabetics. This class is subdivided into oral antidiabetic agents and insulins. Despite a general significant upward trend within the class, some downward pressures were exerted by the Glucpohage Glhcophage XR and Glucovance , trio of oral products. The generic for Glucophage was introduced in early 2002. As that date approached, market share was moved from the more expensive Glucophage averaging $71.99 , per prescription, to the less expensive Glucophage XR and Glucovance at $49.39 and $57.25 respectively. The downward influence of these drugs on mix trend was more than offset by the combined 4 percent market share increase in the glitazones, Avandia and Actos These two . products had average costs per prescription of $120.82 and $139.24, both well above the $64.79 class average. In addition, newer, more expensive insulin products, Humalog and Lantus saw , increased market share in 2001. The narcotic analgesic class experienced an 8.6 percent increase in therapeutic mix in 2001. Despite being one of the highest mix trends in 2001, it is still quite a bit lower than last year's 13.4 percent increase. The reason for the increase in both years was the market share gains achieved by OxyContin One of the more expensive drugs in the class at $237.27 per prescription, . OxyContin gained 0.7 market share percentage points in 2001. That this rise is down from the 1.3 percent increase in 2000 may be a result of doctors' concerns about the potential for abuse of this product in light of its highly publicized illegal use. As has been seen in past years, the continually increasing popularity of Augmentin has contributed to the rise in mix change in the penicillin class. Augmentin with an average cost of , almost three times the class average, increased market share even more than last year, rising from 23.6 percent to 25.7 percent. This increase exceeded the 1.6 percent increase seen in last year's Report and ketamine and glucophage.

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