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IV: STATUS OF IMPLEMENTATION OF ON-GOING PROJECTS AND PROGRAMMES China sector plan for phasing out ODS process agent applications Phase I of the sector plan 11. Phase I of the sector plan was approved in December 2002, which covered the 25 CTC and CFC-113 process agent applications included in List A of Decision X 14. The table below provides the status of implementation of the programme as of December 2006. The total CTC consumption came down from 3, 382 ODP tonnes in 2003 to 460 ODP tonnes in 2006 and the consumption of CFC-113 was completely phased out in 2006. The number of plants that use CTC or CFC-113 as process agent decreased from 32 in 2001 to three in 2006. Actions which have been taken on these plants include closures, conversion to non-ODS alternatives and reducing emission levels. Table 1 in Annex I to this paper presents a summary of the progress achieved as of the end of 2006. 12. Of the three plants which continue using CTC as process agent in the production of chlorinated rubber and chlorosulphonated polyethylene CSM ; , the CSM project has been experiencing difficulties in trying to reduce the level of CTC emissions. The verification report from the World Bank on CTC consumption in Phase I of the sector plan for the year 2006 has reported the following: a ; Jilin Chemical Industrial Co. Ltd. JCIC ; is a chlorosulphonated polyethylene CSM ; producer that uses CTC as a process agent for producing CSM products. The company has three CSM production lines with a total capacity of over 3, 000 MT a. The 1st CSM line of 1, 000 MT a was constructed in 1970 based on its own technology. The line stopped production in June 2004 and was dismantled in May 2006. The 2nd CSM line was constructed in 1989 with an annual capacity of 2, 000 MT a. Its reaction system ceased operation when the 3rd line was installed in 2005. CTC consumption ratios of the old line operations were from 0.35 to 0.38 MT MT. Most of the lost CTC was emitted into the air and or discharged into the water, with little remaining in the final product. In compliance with requirements of the China PA I Sector Plan, the company signed a contract with SEPA to phase out CTC by controlling emissions, and installed its 3rd line in 2004. The new line aims to replace the two old lines and reduce the CTC consumption level from 0.35-0.38 MT MT to 0.06 MT MT. However, due to a malfunction of the imported solvent stripping and double-screw extrusion system, the, for example, protease.
A study in rats showed that, following oral administration, didanosine and or its metabolites were excreted into the milk of lactating rats.
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Adverse effects Treatment-limiting toxicities of didanosine have been dose-related peripheral neuropathy, pancreatitis and gastrointestinal disturbances. The risk of pancreatitis, neuropathy and lactic acidosis is increased when didanosine is combined with stavudine or tenofovir; the combination of didanosine and stavudine is no.
Table 9. Effect of acidic pH on the action of sigma ligands and videx.
Mens lose the entire class with the most common mutations, K103N or Y181C. Failures with some of the newer PIs that use a drug interaction with the PI ritonavir to boost drug exposure lopinavir and fosamprenavir ; appear to lead to no PI-related mutations.14 Therefore, regimens with these agents may also provide good sequencing options. Effective therapy needs to be generally well tolerated both in the short and long term. Toxicities of the components of Trizivir have been well characterized in clinical trials and through postmarketing experience. Zidovudine is commonly associated with short-term gastrointestinal adverse events and, in a small percentage of patients, may cause anemia. In addition, abacavir is associated with a hypersensitivity reaction that most commonly occurs during the first 6 weeks of therapy and requires discontinuation of the agent. This particular reaction has been described in detail, and the symptoms can typically be recognized by most experienced clinicians.2, 5 However, unlike the PI class, efavirenz, and stavudine, Trizivir has not been associated as commonly with alterations in cholesterol or fat stores, and its remedial value as switch therapy in patients who have developed these abnormalities on prior regimens is well documented.8-10 As the components of Trizivir do not significantly inhibit mitochondrial DNA polymerase gamma relative to stavudine, didanosine, and zalcitabine, 15 Trizivir is less likely than triple NRTI combinations containing the latter agents to induce lipoatrophy, peripheral neuropathy, or hyperlactatemia during long-term therapy.15, 16 Lastly, a particular regimen should be convenient for patients to take. Although there are some regimens in which pills are taken once daily, there are few data to suggest that these are better than established twice-daily regimens.2 Trizivir is very convenient for patients because the entire regimen is taken as one pill twice a day. This has the added benefit of one prescription and one prescription copay at the pharmacy. For many patients, this can result in substantial yearly out-of-pocket savings. Summary Based on the parameters outlined above, Trizivir remains a good choice for many patients. Although this regimen may be less efficacious than the lamivudine + zidovudine + elfavirenz combination, there are data demonstrating efficacy similar to that of lamivudine + zidovudine plus a PI. Trizivir is a single-tablet, twice-daily regimen with no specific requirements for food or hydration. The regimen has good short- and long-term tolerability, an acceptable safety profile, and few drug interactions that limit use with other medications. For the minority of patients who may experience virologic failure on this regimen, the majority of NRTIs and all PIs and NNRTIs remain available to construct viable secondary regimens.
DRUG NAME D DIANEAL .5%, 2.5% DIBENZYLINE diclofenac potassium diclofenac sodium, er, xr dicloxacillin dicyclomine didanosine DIDRONEL diflorasone diflunisal digitek digoxin dihydroergotamine DILANTIN 30mg kapseal, infatab dilor dilor-g diltia xt diltiazem, er, xr dilt-xr diphenhydramine diphenoxylate atropine dipivefrin eye drops dipyridamole disopyramide dispas DITROPAN XL dolagesic dolorex dolotic DOVONEX doxazosin mesylate doxepin DOXIL doxorubicin 2 Nutrition, Blood Modifiers, Electrolytes Cardiovascular Medications Musculoskeletal Medications Musculoskeletal Medications Antiinfectives Gastrointestinal Medications Antiinfectives Endocrine Medications Dermatological Medications Musculoskeletal Medications Cardiovascular Medications Cardiovascular Medications Autonomic & CNS Medications Autonomic & CNS Medications Respiratory Medications Respiratory Medications Cardiovascular Medications Cardiovascular Medications Cardiovascular Medications Respiratory Medications Gastrointestinal Medications Ophthalmic Medications Nutrition, Blood Modifiers, Electrolytes Cardiovascular Medications Gastrointestinal Medications Urological Medications Autonomic & CNS Medications Musculoskeletal Medications Ear-Nose-Throat Medications Dermatological Medications Cardiovascular Medications Autonomic & CNS Medications Antineoplastic Immunosuppressant Drugs Antineoplastic Immunosuppressant Drugs TIER NOTES MEDICAL CONDITION and digoxin.
ANTIRETROVIRALS NRTIs- abacavir Ziagen ; , abacavir lamivudine Epzicom ; , abacavir lamivudine zidovudine Trizivir ; , didanosine ddI, Videx, Videx EC ; , emtricitabine Emtriva ; , fluconazole Diflucan ; , lamivudine Epivir, 3TC ; , lamivudine zidovudine Combivir ; , stavudine d4T, Zerit ; , tenofovir Viread ; , tenofovir emtricitabine Truvada ; , zalcitabine ddC, Hivid ; , zidovudine AZT, Retrovir ; . PIs- amprenavir Agenerase ; , atazanavir Reyataz ; , fosamprenavir Lexiva ; , indinavir Crixivan ; , lopinavir ritonavir Kaletra ; , nelfinavir Viracept ; , ritonavir Norvir ; , saquinavir Fortovase, Invirase ; , tipranavir Aptivus ; . NNRTIs- delavirdine Rescriptor ; , efavirenz Sustiva ; , nevirapine Viramune ; . Entry Inhibitors- enfuvirtide Fuzeon ; . OI DRUGS PHS "A1 OI"s- acyclovir, azithromycin Zithromax ; , clarithromycin Biaxin ; , clindamycin, fluconazole Diflucan ; , itraconazole, leucovorin, peg-intron * , pentamidine NebuPent ; , pyrimethamine Daraprim ; , rifabutin Mycobutin ; , ribavirin * , sulfadiazine, TMP SMX Bactrim ; , valganciclovir Valcyte ; . Other OIs- atovaquone Mepron ; , dapsone, epoetin alfa Procrit ; , ethambutol Myambutol ; , filgrastim Neupogen ; , trimethoprim. TREATMENTS FOR METABOLIC DISORDERS Hyperlipidemia- atorvastatin calcium Lipitor ; , gemfibrozil Lopid ; , glipizide, glyburide, metformin, pravastatin Pravachol ; , rosiglitazone Avandia ; . Wasting- estradiol, estrogen conjugated Premarin ; , medroxyprogesterone, megestrol Megace ; , nandrolone decanoate, testosterone enthanate, testosterone gel androgel ; , testim. ALL OTHERS bupropion Wellbutrin ; , carbamazepine, citalopram Celexa ; , desipramine, diphenoxylate atropine, escitalopram Lexapro ; , gabapentin Neurontin ; , Hepatitis A vaccine Havrix ; , Hepatitis A B vaccine Twinrix ; , Hepatitis B vaccine Engenerix-B ; , Imiquimod cream Aldara ; , loperamide, metoclopramide nortriptyline, omeprazole, Pnuemovax 23 vaccine, podofilox solution Condylox ; , prochloroperazine, promethazine Phenergan ; , rantidine, sertraline Zoloft.
On 05 February 2002, the European Commission issued a marketing authorisation valid throughout the European Union for the medicinal product Viread, which contains tenofovir disoproxil fumarate. The marketing authorisation holder responsible for this medicinal product is Gilead Sciences International Ltd. Viread is approved for once-daily administration. On 08 August 1996, the European Commission issued a marketing authorisation valid throughout the European Union for the medicinal product Epivir, which contains lamivudine. The marketing authorisation holder responsible for this medicinal product is GlaxoSmithKline. Epivir is approved for both once and twice-daily administration. The medicinal product Videx, which contains didanosine, was authorised in France on 05 May 1992 and subsequently, in other European Concerned Member States, via mutual recognition procedure after 16 May 1997. The marketing authorisation holder responsible for this medicinal product is Bristol-Myers Squibb and dipyridamole.
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Paediatric patients: since urinary excretion is also a major route of elimination of didanosine in paediatric patients, the clearance of didanosine may be altered in paediatric patients with renal impairment.
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Due to the increase in therapy change rates, the total number of prescriptions filled during the 1-year period rises for the GST versus the open formulary 286 233 prescriptions annually for the GST formulary vs 282 904 prescriptions for the open formulary ; , but the total cost of SSRI therapy is lower for the GST $11.6 million for the GST formulary vs $14.8 million for the open formulary ; Figure 3 ; due to decreased utilization of relatively higher-cost branded agents. The annual pharmacy costs of each formulary can also be represented by a PMPM cost of $0.97 for the GST formulary and $1.23 PMPM for the open formulary a net reduction of $0.26 PMPM for the GST formulary ; . However, although the pharmacy costs associated with the GST formulary are lower, as expected, there is a significant increase in medical costs associated with implementing the GST formulary. Medical costs over a 1-year time frame totaled $178.7 million for the GST formulary as compared with $174.9 million for the open formulary. This can also be represented by a PMPM of $14.89 for the GST formulary and $14.57 for the open formulary, for a net increase of $0.32 PMPM for the GST formulary. When combining medical and pharmacy expenditures over a 1-year time frame, the total cost associated with the open formulary is $189.6 million compared with $190.3 million associated with the GST formulary, for an additional cost of $684 360, or $0.06 PMPM for the total health plan population Figure 3 ; . Medical costs, which include hospitalizations, outpatient visits, and emergency department visits, constitute.
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Mina John; Corey B. Moore; Ian R. James; David Nolan; Richard P. Upton; Elizabeth J. McKinnon; Simon A. Mallal Sex differences in HAART-associated dyslipidaemia Heidemarie Pernerstorfer-Schoen; Bernd Jilma; Alina Perschler; Sibylle Wichlas; Karin Schindler; Andreas Schindl; Armin Rieger; Oswald F. Wagner; Peter Quehenberger Immunologic and virologic response to highly active antiretroviral therapy in the Multicenter AIDS Cohort Study Traci E. Yamashita; John P. Phair; Alvaro Muoz; Joseph B. Margolick; Roger Detels; Stephen J. O'Brien; John W. Mellors; Steven M. Wolinsky; Lisa P. Jacobson CONCISE COMMUNICATION HIV-1 reverse transcriptase sequence in plasma and cerebrospinal fluid of patients with AIDS dementia complex treated with Abacavir E. Randall Lanier; Glenn Sturge; Daniel McClernon; Stephen Brown; Mark Halman; Ned Sacktor; Justin McArthur; Joseph H. Atkinson; David Clifford; Richard W. Price; David Simpson; Gabriel Torres; Jose Catalan; Karen Marder; Chris Power; Colin Hall; Carmen Romero; Bruce Brew EPIDEMIOLOGY & SOCIAL High prevalence of syphilis and other sexually transmitted diseases among sex workers in China: potential for fast spread of HIV Anneke van den Hoek; Fu Yuliang; Nicole H. T. M. Dukers; Chen Zhiheng; Feng Jiangting; Zhang Lina; Zhang Xiuxing HIV-infected pregnant women and vertical transmission in Europe since 1986 European Collaborative Study 18-Month mortality and perinatal exposure to zidovudine in West Africa Franois Dabis; Narcisse Elenga; Nicolas Meda; Valriane Leroy; Ida Viho; Olivier Manigart; Laurence Dequae-Merchadou; Philippe Msellati; Issiaka Sombie; for the DITRAME Study Group Cost-effectiveness of a brief video-based HIV intervention for African American and Latino sexually transmitted disease clinic clients Michael Sweat; Carl O'Donnell; Lydia O'Donnell The fate of free male condoms distributed to the public in South Africa Landon Myer; Catherine Mathews; Francesca Little; Salim S. Abdool Karim EDITORIAL COMMENT Management of hyperlactatemia: no need for routine lactate measurements Kees Brinkman RESEARCH LETTER Differing reverse transcriptase mutation patterns in individuals experiencing viral rebound on first-line regimens with stavudine didanosime and stavudine lamivudine Graeme J. Moyle; Brian G. Gazzard Polymerase chain reaction for Y chromosome to detect semen in cervicovaginal fluid: a prerequisite to assess HIV-specific vaginal immunity and HIV genital shedding.
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One of the ways to contribute to effective post-marketing surveillance would be to pro-actively monitor individuals who are taking the new drugs instead of relying on the current, passive practice of filing adverse reaction reports, for example, zidovudine!
ESSENTIAL OILS ; COSMETIC POWDERS CREAMS POMADES AND OTHER COSMETIC ARTICLES SUBSTANCES INGRESIENTS AND PREPARATIONS OF ALL KINDS ESSENTIAL OILS, AROMA ESSENCES, SYNTHETIC PERFUMES, JANARDAN GOVIND GORE RAW PERFUMES, PERFUMERY INGREDIENTS, ATTARS, OTTOS, PERFUMED OILS, PERFUMES AND PERFUMED OILS FOR SOAPS, PERFUMES LIQUID ; , PERFUMED WATER, PERFUMED BATH SALTS, ESSENCES FOR TOILET PURPOSES, ETHEREAL ESSENTIAL OILS, ETHYL CHLORIDE PERFUMED ; EUGENOL ESSENTIAL OILS ; , COSMETIC POWDERS, CREAMS, POMADES AND OTHER COSMETIC ARTICLES, INGREDIENTS, SUBSTANCES AND PREPARATIONS OF ALL KINDS. ESSENTIAL OILS, AROMA ESSENCES FOR TOILET JANARDAN GOVIND GORE PURPOSES ; , SYNTHETIC PERFUMES, RAW PERFUMES, PERFUMERY INGREDIENTS INCLUDED IN CLASS 3, ATTARS OTTOS PERFUMED OILS, PERFUMES AND PERFUMED OILS FOR SOAPS, PERFUMES LIQUID ; PERFUMED WATER, PERFUMED BATH SALTS ESSENCES FOR TOILET PURPOSES, ETHEREAL ESSENTIAL OILS, ETHYL CHLORIDE PERFUMED ; , EUGNOL ESSENTIAL OILS ; , COSMETIC POWDERS, CREAMS POMADES AND OTHER COSMETIC ARTICLES INGREDIENTS SUBSTANCES, AND PREPARATIONS OF ALL KINDS. DETERGENTS SOAPS AND PERFUMERY INCLUDING TOILET JEYES SANITARY COMPOUNDS ARTICLES AND PREPARATION FOR THE TEETH AND HAIR COMPANY LIMITED PREPARATIONS FOR THE HAIR INCLUDED IN CLASS 3 . JEYES SANITARY COMPOUNDS COMPANY LIMITED TOILET FACE CREAM HAIR OIL POMADE, BRILLIANTINE, SOAP JITENDRA NATH BANERJI. HAIR LOTION, HAIR CREAM, PERFUME, COSMETIC POWDER. SOAPS. K DHARMARAJA PILLAI KODAK LIMITED and motilium.
Lung cancer attributable to indoor radon exposure in france: impact of the risk models and uncertainty analysis.
Antacids containing magnesium or aluminum may cause adverse side effects if given concomitantly with didsnosine tablets and doxepin.
Renal clearance in patients with normal renal function which is equivalent to approximately 400 ml min represents an average of 50% of total body clearance, indicating that active tubular secretion, in addition to glomerular filtration is responsible for the renal elimination of didanosine.
Furthermore, preliminary data suggesting that people are better off getting drugs after early treatment is far from definitive because untreated epileptics are difficult to find and sinequan and didanosine, for instance, rxlist.
CONSTIPATION Constipation is very common in the palliative care patient due to a combination of factors including immobility, reduced food and fluid intake, drugs, bowel pathology and sometimes hypercalcaemia. Assess for these contributing factors and treat as appropriate. Diagnosis is usually made on the basis of history and examination. Abdominal X-ray is rarely required. Guidelines on the use of laxatives in constipation Assess cause and treat where possible. For opioid induced constipation codanthramer 10ml daily ; , codanthramer fort 5ml daily ; or movicol 1 sachet bd R 8 day ; are the drugs of choice. Avoid stimulants such as codanthramer and senna if colic is present. In complete bowel obstruction do not prescribe laxatives without seeking advice. Ask the patient whether they prefer laxative in liquid or tablet form. Review laxatives every 2 days. If bowels haven't moved in 3 days, repeat rectal examination and consider the use of suppositories and enemas. NB. When prescribing codanthramer, patients need to be warned that danthron stains urine red and can cause contact dermatitis. Beware of use in incontinent patients. Movicol: only used for patients able to drink plenty of water.
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Data are number % ; or median IQR ; . ddI didanosine; TDF tenofovir. * Fisher's exact test; Wilcoxon rank sum test.
Cyt c reduction kinetics over a period of 10 to min were followed in standard reaction mixtures with ndHL60 and precultured RAW 246.7 cells activated with 16 M PMA. A progressive initial increase in superoxide peaked between 20 - 30 min and was followed by a decline in ndHL60 Fig. 4 a ; or plateau in RAW 246.7 cells Fig. 4 b ; . The cessation of further cyt c reduction with time may reflect the establishment of a reaction equilibrium in which the rate of cyt c reduction by superoxide is balanced by reoxidation of reduced cyt c Tarpey et al., 2001 ; . On the basis of the data presented we suggest that superoxide readings should be performed either as time kinetics or in case of a single measurement after 20 min incubation, the time of maximal cyt c reduction.
Depakote ; use of these medicines with didanosine may increase the chance of pancreatitis inflammation of the pancreas ; allopurinol e, g.
Bissuel F, Bruneel F, Habersetzer F, et al. Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy. J Intern Med. 1994; 235: 367-371. Brinkman K, ter Hofstede HJ, Burger DM, Smeitink JA, Koopmans PP. Adverse effects of.
Zidovudine doses of 50, 100, and 200 mg, combined with 67, 167, and 250 mg of didanosine were evaluated in 11 asymptomatic hiv-infected patients after receiving 24 weeks of combination therapy in aids clinical trials group protocol 14 the pharmacokinetic parameters of zidovudine and didanosine were similar to those obtained with each drug given as monotherapy in other previously published studies and videx.
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Moreover, didanosine should not be used in combination with ribavirin.
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Severe, life-threatening hepatotoxicity, including fulminant and cholestatic hepatitis, hepatic necrosis, and hepatic failure; patients should be advised to seek medical evaluation immediately if signs and symptoms of hepatitis occur. Severe, life-threatening, and even fatal skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, and hypersensitivity reactions characterized by rash, constitutional findings, and organ dysfunction have occurred with nevirapine treatment. Patients should be monitored intensively during the first 1216 weeks of nevirapine therapy to detect potentially life-threatening hepatotoxicity or skin reactions. A 14-day lead-in period with nevirapine 200 mg daily must be followed strictly. Nevirapine should not be restarted after severe hepatic, skin, or hypersensitivity reactions. Co-administration of ritonavir with certain nonsedating antihistamines, sedative hypnotics, antiarrhythmics, or ergot alkaloids may result in potentially serious or lifethreatening adverse events due to possible effects of ritonavir on hepatic metabolism of certain drugs. No box warning. Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of antiretroviral nucleoside analogues alone or in combination. Fatal lactic acidosis has been reported among pregnant women who received combination of stavudine and didanosine with other antiretroviral combinations. Stavudine and didanosine combination should only be used during pregnancy if the potential benefit clearly outweighs the potential risks. Fatal and non-fatal pancreatitis have occurred when stavudine was part of a combination regimen with didanosine with or without hydroxyurea. Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogs alone or in combination with other antiretrovirals. Zalcitabine can cause severe peripheral neuropathy, use with caution among patients with pre-existing neuropathy. It rare cases, zalcitabine can cause pancreatitis, therapy should be withheld until pancreatitis is excluded. Rare cases of hepatic failure and death have been reported among patients with underlying hepatitis B infection. Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of antiretroviral nucleoside analogues alone or in combination. Zidovudine can be associated with hematologic toxicities, including granulocytopenia and severe anemia, including among advanced HIV patients. Prolonged zidovudine use has been associated with symptomatic myopathy. Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of antiretroviral nucleoside analogues alone or in combination.
Waning of the buffering effects due to the buffers in the didanosine tablets. Although the manufacturer of indinavir suggests that a normal gastric pH environment may be necessary for optimal indinavir absorption, the relatively minor increase in gastric pH that was present after didanosine administration did not appear to affect indinavir exposure. Despite the 5- to 6-h duration of sampling in the present study, the AUC05 AUC08 ratios were 91% 8.4% and 91% 4.6% for the control and didanosine study treatments, respectively. The pharmacokinetic parameters for 800 mg of indinavir reported in this study are similar to those noted previously 2, 4; Crixivan package insert [Merck & Co., Inc.] ; . Furthermore, statistical comparisons between study treatments for both AUC05 and AUC08 yielded the same results. Therefore, indinavir may be taken safely with a light breakfast 1 h following didanosine treatment!
Knupp CA, Shyu WC, Dolin R, Valentine FT, McLaren C, Martin RR, Pittman KA and Barbhaiya RH 1991 ; Pharmacokinetics of didanosine in patients with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex. Clin Pharmacol Ther 49: 523535. Lea AP and Faulds D 1996 ; Stavudine: A review of its pharmacodynamic and pharmacokinetic properties and clinical potential in HIV infection. Drugs 51: 854 864. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ 1951 ; Protein measurement with Folin phenol reagent. J Biol Chem 193: 265275. Mahmood I and Balian JD 1996 ; Interspecies scaling: A comparative study for the prediction of clearance and volume using two or more than two species. Life Sci 59: 579 585. McBurney JJ, Meir H and Hong WG 1964 ; Device for milking mice. J Lab Clin Med 64: 485 487. Omura T and Sato R 1965 ; The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239: 2370 2385. Pai SM, Fettner SH, Hajian G, Cayen MN and Batra VK 1996 ; Characterization of AUCs from sparsely sampled populations in toxicology studies. Pharm Res 13: 12831290. Patel BA, Boudinot FD, Schinazi RF, Gallo JM and Chu CK 1990 ; Comparative pharmacokinetics and interspecies scaling of 3 -azido-3 -deoxythymidine AZT ; in several mammalian species. J Pharmacobio-Dyn 13: 206 211. Powis G, Melder DC and Wilke TJ 1989 ; Human and dog, but not rat, isolated hepatocytes have decreased foreign compound-metabolizing activity compared to liver slices. Drug Metab Dispos 17: 526 531. Qian M, Finco TS, Swagler AR and Gallo JM 1991 ; Pharmacokinetics of 2 , 3 -dideoxyinosine in monkeys. Antimicrob Agents Chemother 35: 2471249. Russell JW and Klunk LJ 1989 ; Comparative pharmacokinetics of new anti-HIV agents: 2 , 3 -dideoxyadenosine and 2 , 3 -dideoxyinosine. Biochem Pharmacol 38: 13851388.
If didanosine is also being taken, it should not be taken simultaneously.
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Pancreatitis * , Peripheral neuropathy. Cautious use with didanosine in pregnant women.
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