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These criteria will identify any patient taking a drug twice a day or more. The alert message will be the same for all dose optimization criteria. There must be a criterion created for each strength because the system must calculate the "max limit" for each strength. Any recipient receiving over the one tablet strength will hit on these criteria. Alert Message: The patient may not be receiving the optimal dosing regimen for this medication. A higher strength exists for this medication, which would allow for a reduced dosing schedule. Utilizing the optimal dosing for this medication would increase patient compliance, decrease Medicaid expenditures, and reduce drug diversion. Conflict Code: ER-Overutiliztion Drugs: Util B Util C Util A Drug X Drug X.
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Canada, UK. Following discussions with Health Canada, AstraZeneca has issued a `Dear Health Care Professional' letter recommending that, due to a trend towards accelerated deaths, clinicians discontinue use of bicalutamide Casodex ; 150mg in patients with localised prostate cancer otherwise managed by watchful waiting i.e., therapy initiated only if signs or symptoms of disease progression occur ; . Approval was granted in November 2002 for bicalutamide 150mg as immediate therapy in some patients with localised prostate cancer for whom surgery or radiation was inappropriate. Health Canada has now withdrawn this approval after reviewing data from a planned second analysis of the Early Prostate Cancer trial programme that show a trend towards accelerated deaths in patients with localised prostate cancer who received bicalutamide 150mg, compared with those who received placebo 196 [25.2%] deaths vs 174 [20.5%] deaths; hazard ratio 1.23; 95% CI 1-1.5 ; . Based on this data, along with the absence of factors suggesting a high risk of disease.
But, he's not in healthcare & gets a bit pasty looking or his eyes glaze over when the dinnertable talk turns to anything illness related, for example, prostrate cancer.
Pharmacists vs. nonpharmacists in adverse drug event detection.
Speak with your doctor or pharmacist if you take, or plan to take, any of the following during treatment and casodex.
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Always remember. If a situation makes you feel uncomfortable, or if it seems risky, leave. C: C means choose the best option. To make the smart choice you have to weigh the outcome before you join in. To do that, you have to ask yourself.
125 EVALUATION OF RAPID DIANGOSTIC ASSAYS FOR VIBRIO CHOLERAE O1: DOES SENSITIVITY VARY BY SKILL LEVEL? Kalluri P, Rahman S, Ansaruzzaman M, Bird M, Faruque ASG, Naheed A, Bhuiyan NA, Nato F, Fournier JM, Bopp C, Mintz ED, Breiman RF, Nair GB. Centers for Disease Control and Prevention, Atlanta, GA; ICDDR, B: Centre for Health and Population Research, Dhaka, Bangladesh; Institut Pasteur, Paris, France. Cholera outbreaks often occur in refugee camps or remote areas with limited laboratory facilities and financial resources. Timely confirmation of outbreaks could be achieved by low-skilled personnel using sensitive diagnostic tests. We report preliminary findings from an ongoing evaluation of diagnostic assays for Vibrio cholerae. We enrolled every 50th symptomatic patient at a diarrhea treatment center in Dhaka, Bangladesh. The SMARTTM, MedicosTM Cholera Dip Stick, and an immunochromatographic dipstick from the Institut Pasteur IP ; were performed on stool by high- and low-skilled staff. Assays were compared to stool culture. We calculated sensitivity Se ; , specificity Sp ; , positive PPV ; and and bisoprolol, for example, flutamide.
1 Wingo PA, Tong T, Bolden S. Cancer statistics, 1995. CA: Cancer J Clin 1995; 45: 8-30. Catalona W. Management of cancer of the prostate. N Engl J Med 1994; 331: 996-1004. Hanks C, Myers C, Scardino P. Cancer of the prostate. In: DeVita VT Jr, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology 5th edition ; . Philadelphia, PA: J.B. Lippincott Co., 1993: 1073-1113. 4 Pollack A, Zagars GK, Kavadi VS. Prostate specific antigen doubling time and disease relapse after radiotherapy for prostate cancer. Cancer 1994; 74: 670-678. Dawson, NA. Treatment of progressive metastatic prostate cancer. Oncology 1993; 7: 17-29. Papac RJ. Bone marrow metastases: a review. Cancer 1994; 74: 2403-2413. Kelley WK, Scher HI, Mazumdar M et al. Prostate-specific antigen as a measure of disease outcome in metastatic hormonerefractory prostate cancer. J Clin Oncol 1993; 11: 607-615. Hussain M, Wolf M, Marshall E et al. Effects of continued androgen-deprivation therapy and other prognostic factors on response and survival in phase II chemotherapy trials for hormone-refractory prostate cancer: a Southwest Oncology Group report. J Clin Oncol 1994; 12: 1868-1875. Taylor CD, Elson P, Trump DL. Importance of continued testicular suppression in hormone refractory prostate cancer. J Clin Oncol 1993; 11: 2167-2172. Geller J. Rational for blockade of adrenal as well as testicular androgens in the treatment of advanced prostate cancer. Semin Oncol 1985; 12: 28-35. Huggins C, Scott W. Bilateral adrenalectomy in prostatic cancer. Clinical features and excretion of 17-ketosteroids and estrogen. Ann Surg 1945; 122: 1031-1041. Chang AYC, Bennett JM, Pandya Asbury R et al. A study of aminogluthamide and hydrocortisone in patients with refractory prostate cancer. J Clin Oncol 1989; 12: 358-360. Younge J, Appel J, Bergsman K. Prolonged remissions with aminogluthamide in advanced prostate cancer. Proc Soc Clin Oncol 1992; 11: 211a. Mahler C, Verhalst J, Denis L. Ketoconazole and liarozole in the treatment of advanced prostate cancer. Cancer 1993; 71: 1068-1073. Tannock I, Gospodarowicz M, Maekin W et al. Treatment of metastatic prostate cancer with low-dose prednisone: evaluation of pain and quality of life as pragmatic indices of response. J Clin Oncol 1989; 7: 590-597. Harland SJ, Duchesne GM. Suramin and prostate cancer: the role of hydrocortisone. Eur J Cancer 1992; 28A: 1295. Hiipakka RA, Liao S. Androgen physiology: androgen receptors and action. In: Degroot LJ et al., eds. Endocrinology 3rd Edition ; . Philadelphia PA: W.B. Saunders, 1995: 2336-2351. 18 Jenster G, van der Korput HAGM, van Vroonhoven C et al. Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization. Mol Endocrinol 1991; 5: 1396-1404. McLeod DG. Antiandrogen drugs. Cancer 1993; 71: 1046-1049. Crawford ED, Eisenberger MA, McLeod DG et al. A controlled trial of leuprolide with or without flutamide in prostatic carcinoma. N Engl J Med 1989; 321: 419-424. Geller J. Basis for hormonal management of advanced prostate cancer. Cancer 1993; 71: 1039-1045. Fossa SD, Hosbach G, Paus E. Flutamide in hormone-resistant prostate cancer. J Urol 1990; 144: 1411-1414. Hobisch A, Culig Z, Radmayr C et al. Distant metastases from prostatic carcinoma express the androgen receptor. Cancer Res 1995; 55: 3068-3072. Ruizeveld de Winter JA, Trapman J, Vermeyt M et al. Androgen receptor expression in human tissues: an immunohistochemical study. J Histochem Cytochem 1991; 39: 927-936. Scher HI, Kelley WK. Flutamide withdrawal syndrome: its impact on clinical trials in hormone refractory prostate cancer. J Clin Oncol 1993; 11: 1566-1572. Figg WD, Sartor O, Cooper MR et al. Prostate specific antigen decline following the discontinuation of flutamide in patients with stage D2 prostate cancer. J Med 1995; 98: 412-414. Olea N, Sakabe K, Soto A et al. The proliferative effect of anti-androgens on the human prostate cancer cell line LNCaP. Endocrinology 1990; 126: 1457-1463. Culig Z, Hobisch A, Cronauer MV et al. Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. Mol Endocrinol 1993; 7: 1541-1550. Suzuki H, Sata N, Watabe Y et al. Androgen receptor mutations in human hormone refractory prostate cancer. J Steroid Biochem Mol Biol 1993; 46: 759-765. Taplin M-E, Bubley GJ, Shuster T et al. Mutation of the androgen-receptor in metastatic androgen-independent prostate cancer. N Engl J Med 1995; 332: 1393-1398. Furr BJ. Casodex: preclinical studies and controversies. Ann NY Acad Sci 1995; 761: 79-96. Shellhammer P, Sharifi R, Block N et al. A controlled trial of bicalutamide versus flutamide, each in combination with leutinizing hormone-releasing hormone analogue therapy, in patients with advanced prostate cancer. Casodex Combination Study Group. Urology 1995; 45: 745-752. Liebertz C, Kelley WK, Theodoulou M et al. High dose casodex for prostate cancer: PSA declines in patients with flutamide withdrawal responses. Proc Soc Clin Oncol 1995; 14: 232a. Small EJ, Carroll PR. Prostate-specific antigen decline after casodex withdrawal: evidence for an antiandrogen withdrawal syndrome. Urology 1994; 43: 408-410.
03.03.05 A US questionnaire survey n 249, aged 12-20 years ; reported that knowledge of Norplant among the general adolescent population was poor. However, young women who were using Norplant were 11 times more likely than those using other types of contraceptive methods to be more knowledgeable about Norplant, having received additional counselling from health care providers.52[EL 3] and zebeta.
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7 to 14 days ; bicalutamide is a man-made drug that is used in the treatment of prostate cancer and bupropion.
The PG preparations should be administered at or near the labor and delivery suite, where uterine activity and fetal heart rate can be monitored continuously. The patient should remain recumbent for at least 30 minutes. The fetal heart rate and uterine activity should be monitored continuously for a period of 30 minutes to 2 hours after administration of the PGE2 gel 42 ; . The patient may be transferred elsewhere if there is no increase in uterine activity and the fetal heart rate is unchanged after this period of observation. Uterine contractions usually are evident in the first hour and exhibit peak activity in the first 4 hours 42, 43 ; . Fetal heart rate monitoring should be continued if regular uterine contractions persist; maternal vital signs should be recorded as well. Because uterine hyperstimulation can occur as late as 9 1 hours after placement of the PGE2 vaginal insert, fetal heart rate and uterine activity should be monitored electronically from the time the device is placed until at least 15 minutes after it is removed 44 ; . This controlledrelease PGE2 vaginal pessary should be removed at the onset of labor 37.
Above statute but also a "physical handicap" as discussed in the Bona fide Occupational Requirement Guidelines S. I. 82 - January 13, 1982 ; . The reference to the older terminology of handicap rather than disability is explained by the earlier date of the Guidelines. There was no challenge to the fact that asthma is a physical disability. Since it was the basis of the dismissal, there is a prima facie case of discrimination by the refusal to continue the employment of Mr. DeJager in contravention of Section 7 of the statute and by pursuing a policy and a practice which discriminates against asthmatics contrary to Section 10. While the policy pursued by the Department of National Defence in respect to asthmatics is directly related to the specific discrimination against Mr. DeJager, Mr. Duval emphasized the latter. Encompassed in the alleged violation of Section 7 of the Canadian Human Rights Act were three related claims. There was discrimination in the dismissal of Mr. DeJager; the refusal to consider him for a temporary medical profile and the refusal to re- muster him to another position within the navy. In respect to the dismissal the reason was asthma and Mr. Mender's attempts to argue that it was the medical downgrading do not change the situation. vol. 3, p. 361, line 14; p. 363, line 4, 12; p. 364, line 17- 24; p. 365, line 4- 8, 17- p. 366, line 2- 17; pp. 369- 372 ; The reclassification came as a result of the diagnosis of asthma and the extent of the downgrading was greater than if it were some other physical problem. The result of the other two claims is less clear. It has been established that discrimination can result from not being considered for a position even if no express application is made. Villeneuve v. Bell Canada Tribunal: N. D. Hesler, May 31, 1985 ; . Thus if Mr. DeJager was entitled to a temporary medical profile, he should have been considered, whether or not he applied for one. Mr. Mender's argument that being kept on for many months after he had received his medical reclassification was more favourable treatment only goes so far. He was dismissed in October, 1982, after being on lighter duties. His condition does seem to have improved after October, 1982 and rather than being dismissed, he could have had his medical profile upgraded from its lower temporary status. Whether Mr. DeJager could have been re- mustered is not clear. His G4 03 classification rendered him unfit for most if not all naval trades. Naval jobs generally require that a person go to sea and that is what Mr. DeJager's medical classification did not allow. There were a very small number of shore jobs available but they appear to be for cases of greater disability and more seniority. Both the question of the temporary medical profile and the re- muster have more to do with accommodation of the disabled to be discussed later. BONA FIDE OCCUPATIONAL REQUIREMENT Having concluded that Mr. DeJager was discriminated against, at least in respect to the dismissal, we now turn to the critical question in this case. Was this discrimination on the basis of a bona fide occupational requirement hereafter referred to as b. The relevant section under the Canadian Human Rights Act is section 14 a ; . 14. It is not a discriminatory practice if a ; any refusal, exclusion, expulsion, suspension, limitation, specification or preference in relation to any employment is established by an employer to be based on a bona fide occupational requirement; . Thus while there is a prima facie case of discrimination, there is no legal discrimination if it is based on a legitimate b. f. o. The logic of this is underscored by Peter Cumming in his recent tribunal decision, Mahon v. C. P. Tribunal: P. Cumming, October 25, 1985 ; . At page 53 he states: In employment cases, therefore, there will be no discrimination if an employer denies a handicapped person a job because he or she is unable to perform the essential duties of the job. This is not a matter of discrimination but of practical business necessity. Parent v. D. N. and A. G. Canada 1980 ; , 1 C. H. 121 is a case in point where the complainant's disability disqualified him from 75% of the job. Earlier in Mahon v. C. P., supra, Peter Cumming stresses the importance of defining equality broadly and not confusing its definition with the need for some practical limitations. Referring to David Baker, "Equality for Disabled People: A Preliminary Analysis of the Impact of Section 15 1 ; of the Charter of Rights and Freedoms" unpublished April 17, 1985 ; he states at page 19 and isoptin.
Call surgeon if urine output less than 120 mL 4 hours in first 24 hours post op Discontinue IV when oral intake greater than 400 mL 8h, IV medications completed and urine output greater than 30 mL h Call surgeon if urine output less than 120 mL 4 hours in first 24 hours post op Discontinue IV when oral intake greater than 400 mL 8h, IV medications completed and urine output greater than 30 mL h randomized controlled trial conducted in patients with gastroesophageal reflux disease compared optimized medical therapy using proton pump inhibitor n 52 ; with laparoscopic Nissen fundoplication n 52 ; . Patients were monitored for 1 year. The primary end point was frequency of gastroesophageal reflux disease symptoms. Surgical patients had improved symptoms, pH control, and overall quality of life health index after surgery at 1 year compared with the medical group. The overall gastroesophageal reflux disease symptom score at 1 year was unchanged in the medical patients, but improved in the surgical patients. Fourteen, for instance, r bicalutamide.
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Alcohol CNS ; Androgens H ; Antiandrogens flutamide, nilutamide, bicalutamide ; H ; Antiarrhythmics CV ; Anticholinergics CNS ; Anticonvulsants CNS ; Antidepressants, MAOI, SSRI, Tri Heterocyclics CNS ; Antihistamines, anticholinergic * CNS ; Antineoplastic cytotoxic drugs H ; Benzodiazepines CNS ; Adrenergic blockers alpha & beta ; H, CV ; Central Alpha-2 Adrenergic Agents CV ; Cimetidine H ; Clofibrate CV ; Decongestants alpha-adrenergic agents ; CNS ; Digoxin H, CV ; Diuretics carbonic anhydrase inhibitors CV ; Diuretics thiazide CV ; Estrogens, conjugated estrogens H ; * anticholinergic antihistamines & decongestants are combination ingredients in many of OTC over the counter, nonprescription ; and prescription cough, cold and allergy products brand generic ; . Ethanol H ; Finasteride H ; Gemfibrozil CV ; Glucocorticoids systemic H ; Haloperidol H, CNS ; Ketoconazole H ; LHRH Agonist goserelin, leuprolide ; H ; Lithium CNS ; Marijuana H, CNS ; Megestrol H ; Methyldopa H, CV ; Metoclopramide H ; Nicotine CNS, CV ; Opiates H, CNS, CV ; Phenothiazines H, CNS ; Reserpine H, CV ; Spironolactone H, CV ; Tetracycline H and doxazosin.
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No 6, 479, 692, wo 01 00608, us patent application no 02 008690 in all the prior art documents bicalutamise is crystallized from ethyl acetate petroleum ether and mesylate and bicalutamide.
Chemotherapy Agents Drugs to treat cancer and cancer treatment side effects ; GENERIC NAME Aldesleukin Altretamine Amifostine Crystalline Aminoglutethimide Anastrozole Arsenic Trioxide Asparaginase Azacitidine BCG Vaccine Intravesical Bexarotene Bicakutamide Bortezomib Busulfan Injection Busulfan Tablet BRAND NAME Proleukin Hexalen Ethyol Cytadren Arimidex Trisenox Elspar Vidaza Tice BCG Targretin Casodex Velcade Busulfex Myleran 13 TIER 4 Prior authorization required. Prior authorization required. Prior authorization required. Prior authorization required. Prior authorization required. Prior authorization required.
Nonetheless, challenges remain. Over the past 20 years a number of government advisory committees and professional medical organizations have developed recommendations to prevent, control and treat viral hepatitis and chronic liver disease. Unfortunately, many of these recommendations have not been implemented. Perhaps clinical, public health, and healthcare policy decision-makers were not aware of the scope and devastation of the diseases, or of how recommendations could be integrated into America's healthcare systems. As a result, few people knew that viral infections can cause hepatitis and most did not know how to protect themselves. Immunizations did not reaching all those who needed and catapres.
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Clinical Summary: It is recommended that women be screened for domestic violence in the health care setting, although there is limited data on screening method preferences and the effectiveness of screening instruments. The authors set out to evaluate 2 screening instruments WAST and PVS ; and 3 screening methods computer, written, face-to-face ; for screening for intimate partner violence IPV ; . Women were recruited from primary, acute, and specialty health care settings, and were all between the ages of 18 and 64. A total of 2461 women were randomized to one of 3 screening methods. All women completed both instruments, plus the CAS, a validated research instrument, to determine the 2 tools agreement with it. The 12-month prevalence was found to range between 4.1%-17.7% depending on method, instrument, and setting. Lower prevalence was found in the FP and women's health clinics vs. the EDs. The PVS and WAST sensitivities and specificities were similar when using the CAS as the gold standard. Women preferred computerized and written methods over face-to-face questioning. Selfreported methods of IPV screening are accurate while being preferred by women. 1. Background a. There is limited information on accuracy, acceptability, and completeness of different IPV screening methods and instruments. 2. Aim a. To contrast 2 screening instruments with the goal of determining an optimal method computer, written, face-toface ; of screening for IPV. The authors studied how well each method gathered information on 12-month prevalence, extent of missing data, and participant preference.
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33, no 5, 1998 - clinical paper a randomised comparison of 'casodex' tm hicalutamide ; 150 mg monotherapy versus castration in the treatment of metastatic and locally advanced prostate cancer tyrrell a , kaisary b , iversen c , anderson d , baert e , tammela f , chamberlain g , webster h , blackledge h a derriford hospital, plymouth, uk; b royal free hospital, london, uk; c rigshospitalet, university of copenhagen, denmark; d royal hallamshire hospital, sheffield, uk; e university hospitals, leuven, belgium; f university hospital, tampere, finland; g heidelberg repatriation hospital, melbourne, australia, and h zeneca pharmaceuticals, alderley park, macclesfield, cheshire, uk address of corresponding author european urology 1998; 7-456 doi: 1 1159 000019634 ; key words anti-androgen 'casodex' tm prostate cancer abstract objectives: to evaluate the efficacy and tolerability of 'casodex' tm monotherapy 150 mg daily ; for metastatic and locally advanced prostate cancer.
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Services to their long-term care residents similar to those provided to their acute care patients. Several types of therapy and such items as over-the-counter medications and special mattresses are not billed to patients in Hospital Act-designated facilities, but are billed in those falling under the Community Care and Assisted Living Act. Another significant difference in the two acts is that Hospital Act-designated facilities have no restrictions on extra room charges which can be imposed for "preferred" accommodation such as semi-private or private rooms ; as opposed to "standard" ward-style rooms with more beds. Room differential charges can exceed $25 per day in these facilities, whereas the upper limit for room differentials in facilities which fall under the Community Care and Assisted Living Act range between $3 and $9 per day, with caps strictly enforced for various categories of preferred accommodation, depending on number of beds, shared versus private lavatory and so forth. There are legitimate grounds for concern that out-of-pocket costs could create financial hardship for facility residents, and that low-income residents, in particular, may be doing without medically necessary items and services. If this is the case, quality of life and health outcomes for residents could be negatively affected. This could result in increased financial cost to the healthcare system if residents forego necessary purchases and suffer adverse medical consequences requiring expensive treatment or admission to acute care. Lack of accurate data regarding out-of-pocket costs to residents in government-funded long-term care facilities is a serious information gap which will hamper government's ability to make policy decisions to maximize quality of life and health outcomes for residents, and minimize cost to the healthcare system itself. A 2002 research study conducted by the Hospital Employees Union of British Columbia reported that out-of-pocket charges are common in BC's long-term care facilities, and that there is no standardization regarding chargeable items and services HEU, 2002, summary ; . The HEU study suggested that for-profit government-funded facilities charge for a greater range of items and services than their not-for-profit counterparts that similar amounts of public funding are providing different levels of insured services to residents. The evidence also suggested that outof-pocket charges are increasing in for-profit and not-for-profit facilities. The HEU study concluded that more research into the prevalence and impacts of out-ofpocket expenditures is necessary, particularly in light of the significant healthcare reform which is under way as a result of funding constraints and demographic changes Pitters, 2002, p. 169.
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In particular, activation of the p53 pathway after treatment with 80 microm bicalutamidd could justify usage of bicalutamide dosages higher than 150 mg daily in androgen-sensitive carcinoma therapy!
Use of relatives as interpreters Domestic violence also may have played a part in two other women's deaths. One was a Late cardiac death, counted in Chapter 15, which highlights a number of areas of concern: A woman who spoke no English and required her children to interpret for her was subject to regular assaults by her husband for a number of years and had been admitted to hospital on several occasions as a result. During one of these admissions she was diagnosed with mitral stenosis. When she became pregnant again she booked late and the fetus died shortly afterwards due to lethal abnormalities. She herself died of atrial fibrillation, some months after delivery, which, in the opinion of the assessors could have been precipitated by an episode of domestic violence. After her delivery the postnatal notes indicate that she had complained of further violence on a number of occasions. As her teenage children were used as interpreters it may have been difficult for the healthcare workers to accurately judge the severity of the situation and the need to offer specific help in dealing with her concerns for her safety. There is no evidence that anyone actively tried to help this woman, who was clearly at risk, with her notes stating she had required operative procedures to fix broken bones in the past. This woman definitively required access to an expert and independent translator. Warning signs ignored In the other case, which is counted and discussed in Chapter 4; Haemorrhage, warning signs were also ignored: This woman lived in very deprived circumstances, used intravenous drugs, had a violent partner and died of abruption. She also had pulmonary hypertension, which required inpatient care during her pregnancy, but when asked to stay she always left hospital against advice, supposedly because she was needed at home. When asked.
Objective: To facilitate, support and develop the national coordination and implementation of behavioural surveillance in England. Methods: Internal activities within CDSC ; included a critical review of behavioural data collected in routine and enhanced STI and HIV surveillance programmes; production of surveillance data derived prevention indicators. Collaborative activities with key external stakeholders included: identification of ongoing and previous behavioural surveillance and research programmes in England; establishing and formalising collaborative links with academic and service providers; collation of data derived from ongoing local and national sexual behavioural surveillance and research programmes. A behavioural surveillance working group, involving key partners from academic, service and community organisations, was established, to define current gaps in provision and to prioritise areas for future development. Results: Minimum data on behavioural determinants of STI HIV transmission are currently collected in a number of existing surveillance programmes. However these vary in their definition and completeness. Although a number of behavioural surveys are currently ongoing in England, these are predominantly with men who have sex with men. While young people and the general population have been the focus of some surveys, other groups at disproportionate burden of HIV and other STI, such as migrant communities have no established behavioural surveillance surveys. Specially designed behavioural surveillance programmes are therefore required to fill the current gaps and this is best achieved through partnerships with external collaborators. Work is also required to develop a nationally agreed set of core behavioural indicators, which draw upon existing validated survey instruments. This will improve comparability of data from diverse sources at both national and local level. Conclusions: National coordination and development of behavioural surveillance activities is feasible but requires the establishment of robust collaborative partnerships.
[1] Blasko JC, Grimm PD, Sylvester JE, et al. The role of external beam radiotherapy with I-125 Pd-103 brachytherapy for prostate carcinoma. Radiother Oncol 2000; 57: 2738. [2] Grimm PD, Blasko JC, Sylvester JE, Meier RM, Cavanagh W. 10year biochemical prostate-specific antigen ; control of prostate cancer with 125 ; I brachytherapy. Int J Radiat Oncol Biol Phys 2001; 51 1 ; : 3140. [3] Wallner K, Roy J, Harrison L. Tumour control and morbidity following transperineal iodine 125 implantation for stage T1 T2 prostatic carcinoma. J Clin Oncol 1996; 14: 44953. [4] Brosman SA, Tokita K. Transrectal ultrasound-guided interstitial radiation therapy for localized prostate cancer. Urology 1991; 38: 3726. [5] Gelblum DY, Potters L, Ashley R, Waldbaum R, Wang X-H, Liebel S. Urinary morbidity following ultrasound-guided transperineal prostate seed implantation. Int J Radiat Oncol Biol Phys 1999; 45: 5967. [6] Stokes SH, Real JD, Adams PW, Clements JC, Wuertzer S, Kan W. Transperineal ultrasound-guided radioactive seed implantation for organ-confined carcinoma of the prostate. Int J Radiat Oncol Biol Phys 1997; 37: 33741. [7] Ragde H, Blasko JC, Grimm PD, Kenny GM, Sylvester JE, Hoak DC, et al. Interstitial iodine-125 radiation without adjuvant therapy for clinically localized prostate cancer. Cancer 1997; 80: 44253. [8] Beyer H, Priestley JB. Biochemical disease-free survival following 125 I prostate implantation. Int J Radiat Oncol Biol Phys 1997; 37: 55963. [9] D'Amico AV, Loeffler S, Harris R, editors. Image-guided diagnosis and treatment of cancer. Totowa NJ ; : Humana Press; 2003. [10] Henderson A, Imail A, Cunningham M, Aldridge S, Loverlock L, Langley SEM, Laing RW, Toxicity and early biochemical outcomes from 125 Iodine prostate brachytherapy: a prospective study. Clin Oncol 2004; 16 2 ; : 95104. [11] Salem N, Simonian-Sauve M, Rosello R, Alzieu C, Gravis G, Maraninchi D, et al. Predictive factors of acute urinary morbidity after iodine-125 brachytherapy for localised prostate cancer: a phase 2 study. Radiother Oncol 2003; 66: 15965. [12] Batterman JJ. I-125 implantation for localized prostate cancer: the Utrecht University experience. Radioth Oncol 2000; 57: 26972. [13] AJCC Cancer Staging Manual 6th Edition. New York: Springer Verlag; 2003. [14] Lee LN, Stock RG, Stone N. Role of hormonal therapy in the management of intermediate- to high-risk prostate cancer treated with permanent radioactive seed implantation. Int J Radiat Oncol Biol Phys 2002; 52: 44452. Ash D, Flynn A, Battermann J, de Reijke T, Lavagnini P, Blank L. ESTRO EAU EORTC recommendations on permanent seed implantation for localized prostate cancer. Radiother Oncol 2000; 57: 31521. Blasko JC, Grimm PD, Sylvester JE, Badiozamani MD, Hoak D, Cavanagh W. Palladium-103 brachytherapy for prostate carcinoma. Int J Radiat Oncol Biol Phys 2000; 46: 83950. Merrick GS, Butler WM, Galbreath RW, Lief JH, Adamovich E. Does hormonal manipulation in conjunction with permanent interstitial brachytherapy, with or without supplemental external beam irradiation, improve the biochemical outcome for men with intermediate or high-risk prostate cancer? BJU Int 2003; 91: 239. Steinberg D, Sauvageot J, Piantadosi S, Epstein J. Corelation of prostate needle biopsy and radical prostatectomy Gleason grade in academic and community settings. J Surg Pathol 1997; 21: 56676. Allsbrook Jr WC, Mangold KA, Johnson MH, Lane RB, Lane CG, Amin MB, et al. Interobserver reproducibility of Gleason grading of prostatic carcinoma: urologic pathologists. Hum Pathol 2001; 32 1 ; : 7480. D'Amico AV, Whittington R, Malkowicz SB, Schultz D, Silver B, Henry L, et al. Clinical utility of the percentage of positive prostate biopsies in defining biochemical outcome after radical prostatectomy for patients with clinically localized prostate cancer. J Clin Oncol 2000; 18: 116472. D'Amico AV, Whittington R, Malkowicz SB, Schultz D, Blank K, Broderick GA, et al. Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA 1998; 280 11 ; : 96974. Terk MD, Stock RG, Stone NN. Identification of patients at increased risk for prolonged urinary retention following radioactive seed implantation of the prostate. J Urol 1998; 160: 137982. Crook J, McLean M, Catton C, Yeung I, Tsihlias J, Pintilie M. Factors influencing risk of acute urinary retention after TRUS-guided permanent prostate seed implantation. Int J Radiat Oncol Biol Phys 2002; 52: 45360. Henderson A, Laing RW, Langley SEM. Is Bicalugamide equivalent to goserelin for prostate volume reduction prior to prostate brachytherapy? Clinical Oncology 2003; 15: 31821.
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The responses to these questions deserve further deliberation for a variety of reasons. It is well known that a large number of offenders were citizens living on the fringes of health care prior to their incarceration. The literature documents that the vast majority of offenders incarcerated in the United States have significant unmet health care needs upon incarceration. For many offenders, incarceration is the first time they have been able to access comprehensive health care services in their lives. This is particularly true for dental services. Many offenders enter and leave the system with communicable diseases STDs, HIV, Tuberculosis, etc. ; . Since the majority reenter society within Florida's communities, their medical management in prison has significant public health consequences. For female offenders in particular, because of their relatively short sentences and the likelihood they have children and may have more, the public health impact is even more significant.
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